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PMID: 6469358 Published · ppublish English Journal Article

Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii.

Infection and immunity ·Vol. 45 ·No. 3 ·1984-09-00 ·Pages 713-7

Schramek S, Kazar J, Sekeyova Z, Freudenberg MA, Galanos C

Abstract

Intraperitoneal inoculation of mice with live or killed Coxiella burnetii phase I or phase II cells induced a marked hyperreactivity to the lethal effect of bacterial endotoxin and was accompanied by a marked hepatosplenomegaly. The degree and duration of hyperreactivity depended on the dose of C. burnetii administered and were higher with phase I than with phase II cells. Sensitization to the lethal effects of endotoxin and induction of splenomegaly by phase I C. burnetii cells also proceeded in the endotoxin-resistant C3H/HeJ strain of mice. Preincubation of C. burnetii cells with the corresponding immune serum significantly diminished the ability of phase I but not phase II cells to induce hyperreactivity to endotoxin.

MeSH Terms
Animals Antibodies, Bacterial/immunology Coxiella/immunology Endotoxins/immunology Liver/immunology Mice Q Fever/immunology Splenomegaly
Chemicals
Antibodies, Bacterial Endotoxins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schramek S
Kazar J
Sekeyova Z
Freudenberg M A
Galanos C
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.45.3.713-717.1984
Published
1984-09-00
Pages
713-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC263355
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.45.3.713-717.1984 PMC Full Text View journal details
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