Antimicrobial spectrum of Win 49375.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 104-7

Jacobus NV, Tally FP, Barza M

Abstract

Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375 had moderate activity against clostridia but little against Bacteroides fragilis. The drug showed a marked inoculum effect at 10(8) CFU/ml and a slight decrease in potency at pH 5.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacteria/drug effects Bacteria, Aerobic/drug effects Bacteria, Anaerobic/drug effects Ciprofloxacin/analogs & derivatives Culture Media Fluoroquinolones Hydrogen-Ion Concentration Microbial Sensitivity Tests Quinolines/pharmacology

Chemicals

Anti-Bacterial Agents Culture Media Fluoroquinolones Quinolines Ciprofloxacin amifloxacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jacobus N V

Tally F P

Barza M

References (4)

4 references, click to expand

Susceptibility of anaerobes to cefoxitin and other cephalosporins.
Antimicrob Agents Chemother. 1975 Feb;7(2):128-32 PMID: 1137364
beta-Lactamase activity in human pus.
J Infect Dis. 1980 Oct;142(4):594-601 PMID: 6969281
In vitro activity of norfloxacin in urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid.
Eur J Clin Microbiol. 1983 Jun;2(3):272-4 PMID: 6224688
In vitro activity of azthreonam, a monobactam antibiotic.
Antimicrob Agents Chemother. 1982 Nov;22(5):832-8 PMID: 6891198

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.26.1.104

Published

1984-07-00

Pages

104-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC179928

Subset

External Links

PubMed source DOI: 10.1128/AAC.26.1.104 PMC Full Text View journal details

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Antimicrobial spectrum of Win 49375.

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