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PMID: 6476814 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 108-9

Galgiani JN, VanWyck DB

Abstract

After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.

MeSH Terms
Amphotericin B/analogs & derivatives,therapeutic use Animals Antifungal Agents/therapeutic use Candidiasis/drug therapy Rats Rats, Inbred Strains
Chemicals
Antifungal Agents methylamphotericin B Amphotericin B
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Galgiani J N
VanWyck D B
References (7)
7 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.26.1.108
Published
1984-07-00
Pages
108-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC179929
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.26.1.108 PMC Full Text View journal details
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