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PMID: 6513929 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.

Molecular and cellular biology ·Vol. 4 ·No. 11 ·1984-11-00 ·Pages 2532-4

van 't Veer LJ, van Kessel AG, van Heerikhuizen H, van Ooyen A, Nusse R

Abstract

Viral mammary tumorigenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called int-1. We have cloned the human homolog of this putative mammary oncogene and compared its structure to that of the mouse gene by heteroduplex analysis. The human int-1 gene was localized on chromosome 12 by use of somatic cell hybrids.

MeSH Terms

Animals Breast Neoplasms/genetics Chromosomes, Human, 6-12 and X Cloning, Molecular Humans Mammary Neoplasms, Experimental/genetics Mice Oncogenes Species Specificity

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

van 't Veer L J

van Kessel A G

van Heerikhuizen H

van Ooyen A

Nusse R

References (12)

12 references, click to expand

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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.4.11.2532-2534.1984

Published

1984-11-00

Pages

2532-4

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC369085

Subset

External Links

PubMed source DOI: 10.1128/mcb.4.11.2532-2534.1984 PMC Full Text View journal details

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Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.

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