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PMID: 6552895 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Methicillin-resistant septal peptidoglycan synthesis in a methicillin-resistant Staphylococcus aureus strain.

Antimicrobial agents and chemotherapy ·Vol. 23 ·No. 4 ·1983-04-00 ·Pages 610-3

Wilkinson BJ, Nadakavukaren MJ

Abstract

In a methicillin-resistant Staphylococcus aureus strain, electron micrographs showed that cell wall septa continued to be formed in the presence of methicillin, although they became distorted and enlarged. The results indicated that peripheral cell wall synthesis was inhibited. It is concluded that a methicillin-resistant mode of septal peptidoglycan synthesis is an important determinant of methicillin resistance.

MeSH Terms
Bacterial Proteins Carrier Proteins/metabolism Cell Wall/metabolism Hexosyltransferases Methicillin/pharmacology Muramoylpentapeptide Carboxypeptidase Penicillin Resistance Penicillin-Binding Proteins Peptidoglycan/biosynthesis Peptidyl Transferases Staphylococcus aureus/drug effects,metabolism,ultrastructure
Chemicals
Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins Peptidoglycan Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase Methicillin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilkinson B J
Nadakavukaren M J
References (10)
10 references, click to expand
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    Eur J Biochem. 1982 Oct;127(3):553-8 PMID: 7173195
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.23.4.610
Published
1983-04-00
Pages
610-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC184710
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.23.4.610 PMC Full Text View journal details
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