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PMID: 6553055 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

The Journal of biological chemistry ·Vol. 258 ·No. 14 ·1983-07-25 ·Pages 8547-9

Sinensky M, Logel J

Abstract

Mevinolin is demonstrated to inhibit the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in Chinese hamster ovary cells. Evidence is presented that this effect of mevinolin is not general to degradation of total cellular proteins and is not due to the block to mevalonate synthesis produced by this compound.

MeSH Terms

Animals Cell Line Cricetinae Cricetulus Female Hydroxymethylglutaryl CoA Reductases/genetics Hydroxymethylglutaryl-CoA Reductase Inhibitors Kinetics Lovastatin Naphthalenes/pharmacology Ovary

Chemicals

Hydroxymethylglutaryl-CoA Reductase Inhibitors Naphthalenes Lovastatin Hydroxymethylglutaryl CoA Reductases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sinensky M

Logel J

Article Info

Journal

The Journal of biological chemistry

Abbr.

J Biol Chem

ISSN

0021-9258

Published

1983-07-25

Pages

8547-9

Language

English

Region

United States

NLM ID

2985121R

Subset

Grants

NICHD NIH HHS · HD02080 · United States

NHLBI NIH HHS · HL24732 · United States

External Links

PubMed source View journal details

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Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

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