Home LiteratureArticle Details
PMID: 656321 Published · ppublish English Journal Article

Effect of carrageenan on activity of the mononuclear phagocyte system in the mouse.

British journal of experimental pathology ·Vol. 59 ·No. 2 ·1978-04-00 ·Pages 213-9

Fowler EF, Thomson AW

Abstract

Injection of 5 mg carrageenan caused hepatosplenomegaly and thymic involution and resulted in temporary blockade of the mononuclear phagocyte system (MPS). Impaired MPS activity was shown by decreased hepatic phagocytosis of i.v. injected colloidal carbon and 51Cr-labelled sheep red blood cells (SRBC). Depression of Kupffer cell activity was dependent on carrageenan dose, route of administration and interval between carrageenan and particle injection. Reduction in hepatic uptake of SRBC was accompanied by increased localization of these cells within the spleen.

MeSH Terms
Animals Carbon Carrageenan/pharmacology Depression, Chemical Female Kidney/immunology Liver/immunology Mice Organ Size/drug effects Phagocytosis/drug effects Spleen/immunology
Chemicals
Carbon Carrageenan
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fowler E F
Thomson A W
References (22)
22 references, click to expand
  1. Influence of reticuloendothelial blockade on the induction of tolerance and immunity by polysaccharides.
    Immunology. 1976 Feb;30(2):221-7 PMID: 57095
  2. The differential suppression of antigen, lymphokine and mitogen-induced delayed hypersensitivity-type skin reactions by carrageenan.
    Int Arch Allergy Appl Immunol. 1973;44(3):409-21 PMID: 4708777
  3. Alleviation of carrageenan-induced hepatotoxicity and acronecrosis by aprotinin.
    Br J Exp Pathol. 1977 Jun;58(3):260-7 PMID: 301397
  4. A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression.
    Immunology. 1977 Sep;33(3):423-32 PMID: 332622
  5. Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation.
    Biomedicine. 1976 May;24(2):102-6 PMID: 776242
  6. Potentiation of tumour growth by carrageenan.
    Transplantation. 1977 Nov;24(5):397-400 PMID: 919030
  7. Increased antibody production following depression of hepatic phagocytosis.
    Clin Exp Immunol. 1975 Apr;20(1):155-9 PMID: 1106919
  8. Effects of oestrogens and pregnancy on the distribution of sheep erythrocytes and the antibody response in mice.
    Clin Exp Immunol. 1975 Apr;20(1):179-86 PMID: 1106921
  9. Role of cellular proliferation in the stimulation of MPS phagocytic activity.
    Br J Exp Pathol. 1975 Aug;56(4):314-21 PMID: 1174456
  10. The effect of carrageenan on the establishment of delayed hypersensitivity.
    Int Arch Allergy Appl Immunol. 1971;41(4):628-36 PMID: 4108563
  11. An examination of the cytotoxic effects of silica on macrophages.
    J Exp Med. 1966 Aug 1;124(2):141-54 PMID: 4288309
  12. Poly-2-vinylpyridine N-oxide reverses the immunosuppressive effects of silica and carrageenan.
    Transplantation. 1972 Mar;13(3):343-5 PMID: 4336591
  13. The effect of Corynebacterium parvum on the structure and function of the lymphoid system in mice.
    Eur J Cancer. 1974 Feb;10(2):115-20 PMID: 4611769
  14. Suppression of primary immunization by carrageenan - a macrophage toxic agent.
    Immunol Commun. 1972;1(6):615-25 PMID: 4616009
  15. The immunodepressant effect of carrageenin.
    J Reticuloendothel Soc. 1972 Mar;11(3):253-62 PMID: 5032560
  16. Spectrum and possible mechanism of carrageenan cytotoxicity.
    Am J Pathol. 1971 Aug;64(2):387-404 PMID: 5142272
  17. Stimulation of humoral antibody formation by polyanions. V. Relationship between enhancement of sheep red blood cell uptake by the spleen and adjuvant action of dextran sulfate.
    Eur J Immunol. 1971 Dec;1(6):429-32 PMID: 4947880
  18. The effect of cholesterol oleate treatment of mice on the rosette forming cell response against sheep erythrocytes.
    Q J Exp Physiol Cogn Med Sci. 1976 Jan;61(1):45-55 PMID: 1051691
  19. The recovery of hepatic phagocytosis after blockade of Kupffer cells.
    J Reticuloendothel Soc. 1974 Aug;16(2):75-86 PMID: 4376177
  20. The effect of colloidal carbon on the organ distribution of sheep red cells and the immune response.
    Immunology. 1972 Apr;22(4):685-94 PMID: 4552641
  21. The mechanism of the adjuvant effect of dextran sulphate.
    Immunology. 1974 Feb;26(2):383-92 PMID: 4605294
  22. Promotion of tumor growth in vivo by antimacrophage agents.
    J Natl Cancer Inst. 1976 Dec;57(6):1355-61 PMID: 187804
Article Info
Journal
British journal of experimental pathology
Abbr.
Br J Exp Pathol
ISSN
0007-1021
Published
1978-04-00
Pages
213-9
Language
English
Region
England
NLM ID
0372543
PMCID
PMC2041325
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2