Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.

British journal of pharmacology ·Vol. 62 ·No. 4 ·1978-04-00 ·Pages 529-36

Goldberg A, Meredith PA, Miller S, Moore MR, Thompson GG

Abstract

1 Pretreatment of rats with intraperitoneal injections of lead was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. 2 The activity of the rate-limiting enzyme of haem biosynthesis, delta-aminolaevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. 3 The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. 4 The activity of the haem catabolic enzyme, haem oxygenase, was increased by lead pretreatment.

MeSH Terms

5-Aminolevulinate Synthetase/metabolism Animals Heme/biosynthesis In Vitro Techniques Lead Poisoning/metabolism Liver/drug effects,metabolism Male Microsomes, Liver/drug effects,metabolism Mixed Function Oxygenases/metabolism Pharmaceutical Preparations/metabolism Rats

Chemicals

Pharmaceutical Preparations Heme Mixed Function Oxygenases 5-Aminolevulinate Synthetase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Goldberg A

Meredith P A

Miller S

Moore M R

Thompson G G

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24 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1978.tb07757.x

Published

1978-04-00

Pages

529-36

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1668043

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1978.tb07757.x PMC Full Text View journal details

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Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.

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