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PMID: 6579549 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biological significance of carbohydrate chains on monoclonal antibodies.

Nose M, Wigzell H

Abstract

We have prepared monoclonal hapten-specific mouse IgG2b antibodies depleted of asparagine-linked carbohydrate chains by treating the hybridoma cells with tunicamycin. The carbohydrate-deficient antibodies behaved in an identical manner to the normal antibodies with regard to fine antigen-binding reactivity (a Fab fragment feature) and protein A binding capacity [a feature requiring integrity at the CH2 and CH3 domain-interaction regions in the constant region of the heavy chain (CH)]. However, they lost the ability to activate complement, to bind to Fc receptors on macrophages, and to induce antibody-dependent cellular cytotoxicity. Furthermore, antigen-antibody complexes produced from such carbohydrate-deficient antibodies failed to be eliminated rapidly from the circulation. We conclude that removal of carbohydrate chains from IgG molecules may have a profound and highly select impact on the biological activity to these antibodies.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antibody-Dependent Cell Cytotoxicity Antigen-Antibody Complex Binding Sites, Antibody Complement Activation Glycoproteins/immunology Kinetics Mice Receptors, Fc/immunology Staphylococcal Protein A/immunology Structure-Activity Relationship Tunicamycin/pharmacology
Chemicals
Antibodies, Monoclonal Antigen-Antibody Complex Glycoproteins Receptors, Fc Staphylococcal Protein A Tunicamycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nose M
Wigzell H
References (34)
34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1983-11-00
Pages
6632-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391224
Subset
IM
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