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PMID: 658257 Published · ppublish English Journal Article

Effect of variations in temperature on antimuscarinic activity in guinea-pig atria.

Experientia ·Vol. 34 ·No. 5 ·1978-05-15 ·Pages 641-3

Li CK, Mitchelson F

Abstract

The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.

MeSH Terms
Alkaloids/pharmacology Animals Atropine Derivatives/pharmacology Gallamine Triethiodide/pharmacology Guinea Pigs Heart Atria/drug effects Myocardial Contraction/drug effects Parasympatholytics/pharmacology Pregnadienes/pharmacology Pyrrolidines/pharmacology Temperature
Chemicals
Alkaloids Atropine Derivatives Parasympatholytics Pregnadienes Pyrrolidines Gallamine Triethiodide stercuronium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Li C K
Mitchelson F
References (18)
18 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01937009
Published
1978-05-15
Pages
641-3
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01937009
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