Home LiteratureArticle Details

PMID: 6583673 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Brain-specific genes have identifier sequences in their introns.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 3 ·1984-02-00 ·Pages 713-7

Milner RJ, Bloom FE, Lai C, Lerner RA, Sutcliffe JG

Abstract

The 82-nucleotide identifier (ID) sequence is present in the rat genome in 1-1.5 X 10(5) copies and in cDNA clones of precursors of brain-specific mRNAs. One brain-specific gene contains more than one ID sequence in its introns. There is an excess of ID sequences to brain genes, and some ID sequences appear to have been inserted as mobile elements into other genetic locations. Therefore, brain genes contain ID sequences in their introns, but not all ID sequences are located in brain gene introns. A brain ID consensus sequence has been obtained by comparing 8 ID nucleotide sequences.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Brain/metabolism Cloning, Molecular DNA/metabolism Genes Nerve Tissue Proteins/genetics Nucleic Acid Hybridization Rats Repetitive Sequences, Nucleic Acid

Chemicals

Nerve Tissue Proteins DNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Milner R J

Bloom F E

Lai C

Lerner R A

Sutcliffe J G

References (16)

16 references, click to expand

Polymorphism near the rat prolactin gene caused by insertion of an Alu-like element.
Nature. 1983 Sep 8-14;305(5930):159-60 PMID: 6310412
Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides.
Cell. 1983 Jul;33(3):671-82 PMID: 6347394
Gene regulation for higher cells: a theory.
Science. 1969 Jul 25;165(3891):349-57 PMID: 5789433
Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes.
Cell. 1978 Dec;15(4):1145-56 PMID: 264240
The rat serum albumin gene: analysis of cloned sequences.
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3256-60 PMID: 158758
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4317-21 PMID: 228296
Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA.
Cell. 1980 May;20(1):131-41 PMID: 6248230
Speculations on RNA splicing.
Cell. 1981 Mar;23(3):643-6 PMID: 7226224
Primary structure and evolution of rat growth hormone gene.
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4867-71 PMID: 6946433
Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements.
Nature. 1981 Dec 17;294(5842):626-31 PMID: 7312050
Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.
Science. 1982 Sep 3;217(4563):934-6 PMID: 6287572
Repetitive sequences in eukaryotic DNA and their expression.
Annu Rev Biochem. 1982;51:813-44 PMID: 7051966
Common 82-nucleotide sequence unique to brain RNA.
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4942-6 PMID: 6956902
The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.
Nature. 1982 Nov 25;300(5890):330-5 PMID: 6927856
Structural analysis of gene loci for rat U1 small nuclear RNA.
Nucleic Acids Res. 1983 Mar 25;11(6):1791-801 PMID: 6188110
Gene expression in rat brain.
Nucleic Acids Res. 1983 Aug 25;11(16):5497-520 PMID: 6193485

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.81.3.713

Published

1984-02-00

Pages

713-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC344905

Subset

Grants

NIGMS NIH HHS · GM 32355 · United States

Databases

GENBANK

K01676, K01677

External Links

PubMed source DOI: 10.1073/pnas.81.3.713 PMC Full Text View journal details

Analysis Services

Brain-specific genes have identifier sequences in their introns.

Contact

WeChat Official Account