Home LiteratureArticle Details
PMID: 6585139 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Easy calculations of lod scores and genetic risks on small computers.

American journal of human genetics ·Vol. 36 ·No. 2 ·1984-03-00 ·Pages 460-5

Lathrop GM, Lalouel JM

Abstract

A computer program that calculates lod scores and genetic risks for a wide variety of both qualitative and quantitative genetic traits is discussed. An illustration is given of the joint use of a genetic marker, affection status, and quantitative information in counseling situations regarding Duchenne muscular dystrophy.

MeSH Terms
Computers Creatine Kinase/genetics Genetic Counseling Genetic Linkage Genetic Markers Heterozygote Humans Lod Score Muscular Dystrophies/enzymology,genetics Pedigree Risk Software
Chemicals
Genetic Markers Creatine Kinase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lathrop G M
Lalouel J M
References (8)
8 references, click to expand
  1. A general model for the genetic analysis of pedigree data.
    Hum Hered. 1971;21(6):523-42 PMID: 5149961
  2. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.
    Am J Hum Genet. 1974 Sep;26(5):588-97 PMID: 4422075
  3. Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees.
    Hum Hered. 1975;25(2):95-105 PMID: 1150306
  4. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
    Am J Hum Genet. 1980 May;32(3):314-31 PMID: 6247908
  5. Resolution of linkage for irregular phenotype systems.
    Hum Hered. 1981;31(1):3-7 PMID: 7250988
  6. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.
    Nature. 1982 Nov 4;300(5887):69-71 PMID: 6982420
  7. Regular two-allele and three-allele phenotype systems. I.
    Am J Hum Genet. 1953 Sep;5(3):193-235 PMID: 13080248
  8. Sequential tests for the detection of linkage.
    Am J Hum Genet. 1955 Sep;7(3):277-318 PMID: 13258560
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1984-03-00
Pages
460-5
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684427
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2