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PMID: 6585786 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

On the mechanism of energy transduction in myosin subfragment 1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 7 ·1984-04-00 ·Pages 2060-4

Botts J, Takashi R, Torgerson P, Hozumi T, Muhlrad A, Mornet D, Morales MF

Abstract

It is proposed that the myosin subfragment 1 moiety of the muscle contractile apparatus is a self-contained "engine" whose operational plan is based on the interactive nature of ATP (or degradation intermediate) binding and actin binding, made possible by an intersite communication system. It is suggested that the spatial information required for examining this engine can, at least provisionally, be derived from fluorescence resonance energy transfer measurements interpreted by the Förster equation and that the existence of an intersite communication system can be deduced from piece-wise detection of interacting pairs of points.

MeSH Terms
Actins/metabolism Adenosine Triphosphate/metabolism Animals Energy Transfer Kinetics Models, Biological Models, Molecular Muscle Contraction Muscles/metabolism Myosin Subfragments Myosins/metabolism Peptide Fragments/metabolism Protein Binding Protein Conformation Rabbits
Chemicals
Actins Myosin Subfragments Peptide Fragments Adenosine Triphosphate Myosins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Botts J
Takashi R
Torgerson P
Hozumi T
Muhlrad A
Mornet D
Morales M F
References (52)
52 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.7.2060
Published
1984-04-00
Pages
2060-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345436
Subset
IM
Grants
NHLBI NIH HHS · HL-16683 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.7.2060 PMC Full Text View journal details
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