Home LiteratureArticle Details

PMID: 6591853 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro activities of enoxacin and 17 other antimicrobial agents against multiply resistant, gram-negative bacteria.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 97-100

Rudrik JT, Cavalieri SJ, Britt EM

Abstract

Enoxacin (CI-919) was evaluated for activity against 120 multiply resistant clinical isolates of the family Enterobacteriaceae and Pseudomonas aeruginosa. The MIC of enoxacin for 95% of the strains tested was less than or equal to 2 micrograms/ml. Approximately 90% of the isolates were susceptible to enoxacin, norfloxacin, ceftazidime, moxalactam, cefotaxime, cefoperazone, and amikacin. Marked resistance to the other seven antimicrobial agents tested was observed.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Enoxacin Enterobacteriaceae/drug effects Gram-Negative Bacteria/drug effects Naphthyridines/pharmacology

Chemicals

Anti-Bacterial Agents Naphthyridines Enoxacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rudrik J T

Cavalieri S J

Britt E M

References (7)

7 references, click to expand

Tentative interpretive standards for disk diffusion susceptibility testing with norfloxacin (MK-0366, AM-715).
Antimicrob Agents Chemother. 1983 Feb;23(2):256-60 PMID: 6220671
In vitro antibacterial properties of AT-2266, a new pyridonecarboxylic acid.
Antimicrob Agents Chemother. 1983 May;23(5):641-8 PMID: 6575721
In vitro activity of CI-919 (AT-2266), an oral antipseudomonal compound.
Antimicrob Agents Chemother. 1983 May;23(5):658-63 PMID: 6223577
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.
Antimicrob Agents Chemother. 1983 Nov;24(5):754-63 PMID: 6229216
Pharmacokinetics of AT-2266 administered orally to mice, rats, dogs, and monkeys.
Antimicrob Agents Chemother. 1983 Jul;24(1):54-60 PMID: 6226241
In vitro and in vivo antibacterial activity of AT-2266.
Antimicrob Agents Chemother. 1983 Jul;24(1):78-84 PMID: 6226242
Activity of AT-2266 compared with those of norfloxacin, pipemidic acid, nalidixic acid, and gentamicin against various experimental infections in mice.
Antimicrob Agents Chemother. 1983 May;23(5):742-9 PMID: 6223579

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.26.1.97

Published

1984-07-00

Pages

97-100

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC179926

Subset

External Links

PubMed source DOI: 10.1128/AAC.26.1.97 PMC Full Text View journal details

Analysis Services

In vitro activities of enoxacin and 17 other antimicrobial agents against multiply resistant, gram-negative bacteria.

Contact

WeChat Official Account