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PMID: 6605410 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.

The Journal of experimental medicine ·Vol. 158 ·No. 5 ·1983-11-01 ·Pages 1745-50

Sunshine GH, Gold DP, Wortis HH, Marrack P, Kappler JW

Abstract

In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens/immunology Hemocyanins Histocompatibility Antigens Class II/immunology Hybridomas/immunology Interleukin-2/biosynthesis Male Mice Mice, Inbred Strains Ovalbumin/immunology Spleen/cytology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antigens Histocompatibility Antigens Class II Interleukin-2 Ovalbumin Hemocyanins keyhole-limpet hemocyanin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sunshine G H
Gold D P
Wortis H H
Marrack P
Kappler J W
References (17)
17 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.158.5.1745
Published
1983-11-01
Pages
1745-50
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187132
Subset
IM
Grants
NIAID NIH HHS · AI-07077 · United States
NIAID NIH HHS · AI-15803 · United States
NIAID NIH HHS · AI-18785 · United States
External Links
PubMed source DOI: 10.1084/jem.158.5.1745 PMC Full Text View journal details
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