Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.

Nucleic acids research ·Vol. 11 ·No. 22 ·1983-11-25 ·Pages 8031-6

Froehler BC, Matteucci MD

Abstract

Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.

MeSH Terms

Adenosine/analogs & derivatives Amidines Deoxyadenosines Formamides Indicators and Reagents Kinetics Oligodeoxyribonucleotides/chemical synthesis Oligonucleotides/chemical synthesis Structure-Activity Relationship

Chemicals

Amidines Deoxyadenosines Formamides Indicators and Reagents Oligodeoxyribonucleotides Oligonucleotides N(6)-benzyladenosine Adenosine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Froehler B C

Matteucci M D

References (3)

3 references, click to expand

Selective N-debenzoylation of N,O-polybenzoylucleosides.
Tetrahedron Lett. 1968 Apr;(22):2621-4 PMID: 5646263
Synthesis of oligodeoxyribonucleotides on silica gel support.
Nucleic Acids Res. 1981 Jun 25;9(12):2807-17 PMID: 6269061
Syringe method for stepwise chemical synthesis of oligonucleotides.
Nucleic Acids Res. 1982 May 25;10(10):3249-60 PMID: 7099961

Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/11.22.8031

Published

1983-11-25

Pages

8031-6

Language

English

Region

England

NLM ID

0411011

PMCID

PMC326557

Subset

External Links

PubMed source DOI: 10.1093/nar/11.22.8031 PMC Full Text View journal details

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Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.

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