Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation.

Agents and actions ·Vol. 14 ·No. 1 ·1984-01-00 ·Pages 72-5

Zídek Z, Masek K, Sedivý F

Abstract

Synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), has been tested for activity against acute inflammation. In all models employed (Bayol + Arlacel paw oedema in rats, carrageenan pleurisy in rats, and carrageenan of dextran paw oedema in mice), MDP given in admixture with the phlogistic agents significantly lowered the resulting inflammatory reaction by about 30-40%. 0.1-0.2 mg of MDP per animal was applied. The mechanism of anti-inflammatory activity of this substance remains unknown.

MeSH Terms

Acetylmuramyl-Alanyl-Isoglutamine/pharmacology Animals Anti-Inflammatory Agents Carrageenan/antagonists & inhibitors Edema/prevention & control Male Mice Pleurisy/prevention & control Rats Rats, Inbred Lew

Chemicals

Anti-Inflammatory Agents Acetylmuramyl-Alanyl-Isoglutamine Carrageenan

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zídek Z

Masek K

Sedivý F

References (17)

17 references, click to expand

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Article Info

Journal

Agents and actions

Abbr.

Agents Actions

ISSN

0065-4299

DOI

10.1007/BF01966836

Published

1984-01-00

Pages

72-5

Language

English

Region

Switzerland

NLM ID

0213341

Subset

External Links

PubMed source DOI: 10.1007/BF01966836

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Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation.

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