Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.

British journal of clinical pharmacology ·Vol. 16 ·No. 2 ·1983-08-00 ·Pages 185-7

Dew MJ, Ryder RE, Evans N, Evans BK, Rhodes J

Abstract

5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.

MeSH Terms

Adult Aged Aminosalicylic Acids/administration & dosage,blood,metabolism Colitis, Ulcerative/metabolism Colon/metabolism Female Humans Intestines/diagnostic imaging Male Mesalamine Middle Aged Radiography Tablets, Enteric-Coated Time Factors

Chemicals

Aminosalicylic Acids Tablets, Enteric-Coated Mesalamine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Dew M J

Ryder R E

Evans N

Evans B K

Rhodes J

References (4)

4 references, click to expand

An experiment to determine the active therapeutic moiety of sulphasalazine.
Lancet. 1977 Oct 29;2(8044):892-5 PMID: 72239
HA-966 effects on striatal dopamine metabolism: implications for dopamine compartmentalization.
J Pharm Pharmacol. 1980 Jan;32(1):67-9 PMID: 6102135
An oral preparation to release drugs in the human colon.
Br J Clin Pharmacol. 1982 Sep;14(3):405-8 PMID: 7126413
Maintenance of remission in ulcerative colitis with oral preparation of 5-aminosalicylic acid.
Br Med J (Clin Res Ed). 1982 Oct 9;285(6347):1012 PMID: 6127137

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1983.tb04983.x

Published

1983-08-00

Pages

185-7

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1427967

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1983.tb04983.x PMC Full Text View journal details

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Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.

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