Home LiteratureArticle Details
PMID: 6616003 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Dependence of cellular potential on ionic concentrations. Data supporting a modification of the constant field equation.

Biophysical journal ·Vol. 43 ·No. 2 ·1983-08-00 ·Pages 149-56

Chang DC

Abstract

The resting potential in the squid axon has been measured at various concentrations of Cl, K, Na, and Ca ions. The results of these measurements are compared with the Goldman-Hodgkin-Katz (GHK) equation and a modified constant field equation. This modified equation was derived by including currents carried by divalent ions and the effects of the unstirred layer and the periaxonal space. It is shown that, although the GHK equation can fit the V vs. [K]o data well, it has difficulty explaining the observed dependence of V on [Na]o when the axon is bathed in K-free artificial sea water. The use of the modified constant field equation removes this difficulty.

MeSH Terms
Animals Axons/physiology Cell Membrane Permeability Chlorides/physiology Decapodiformes Electrolytes/physiology In Vitro Techniques Membrane Potentials/drug effects Osmolar Concentration Potassium/physiology Seawater/analysis Silver/pharmacology
Chemicals
Chlorides Electrolytes Silver Potassium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chang D C
References (13)
13 references, click to expand
  1. The effect of ions upon neuromuscular transmission in a herbivorous insect.
    J Physiol. 1957 Aug 29;138(1):119-39 PMID: 13463802
  2. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo.
    J Physiol. 1952 Apr;116(4):449-72 PMID: 14946713
  3. Osmotic flow.
    Symp Soc Exp Biol. 1965;19:75-85 PMID: 5849054
  4. THE EFFECT OF DILUTING THE INTERNAL SOLUTION ON THE ELECTRICAL PROPERTIES OF A PERFUSED GIANT AXON.
    J Physiol. 1964 Apr;170:541-60 PMID: 14165694
  5. The cellular resting and action potentials: interpretation based on the association-induction hypothesis.
    Physiol Chem Phys. 1982;14(1):47-96 PMID: 6294693
  6. Depolarization and calcium entry in squid giant axons.
    J Physiol. 1971 Nov;218(3):709-55 PMID: 5133953
  7. Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibers.
    J Physiol. 1951 Feb;112(3-4):496-508 PMID: 14825229
  8. The action of calcium on the electrical properties of squid axons.
    J Physiol. 1957 Jul 11;137(2):218-44 PMID: 13449874
  9. A physical model of nerve axon--I. Ionic distribution, potential profile, and resting potential.
    Bull Math Biol. 1977;39(1):1-22 PMID: 830186
  10. Ionic movements and electrical activity in giant nerve fibres.
    Proc R Soc Lond B Biol Sci. 1958 Jan 1;148(930):1-37 PMID: 13494473
  11. Mechanism of action of propranolol on squid axon membranes.
    J Pharmacol Exp Ther. 1973 Jan;184(1):155-62 PMID: 4686004
  12. The effect of sodium ions on the electrical activity of giant axon of the squid.
    J Physiol. 1949 Mar 1;108(1):37-77 PMID: 18128147
  13. Effects of internal and external ionic environment on excitability of squid giant axon. A macromolecular approach.
    J Gen Physiol. 1965 Jul;48(6):1095-123 PMID: 5855510
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(83)84335-5
Published
1983-08-00
Pages
149-56
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1329244
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(83)84335-5 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2