Home LiteratureArticle Details
PMID: 6616623 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA?

Cell ·Vol. 34 ·No. 2 ·1983-09-00 ·Pages 619-27

Jennings PA, Finch JT, Winter G, Robertson JS

Abstract

Subgenomic RNAs (sgRNAs) were isolated from defective interfering virus produced by high multiplicity passage of the human influenza strain A/PR/8/34. Cloning and sequencing of 35 unique sgRNAs revealed that many were about 400 nucleotides long, containing about 200 nucleotides from each of the 5' and 3' ends of a full-length segment. Most of the sgRNAs were derived from segment 1, but there were examples from six other segments, including those encoding the haemagglutinin and neuraminidase. Our analysis of the sequence rearrangements found in sgRNAs indicates that they may be generated from the standard viral segments by a jumping viral polymerase that makes transitions between adjacent regions of the RNA template in the ribonucleoprotein tertiary structure.

MeSH Terms
Base Sequence Cloning, Molecular DNA-Directed RNA Polymerases/metabolism Influenza A virus/genetics Microscopy, Electron Nucleic Acid Conformation RNA, Viral/analysis
Chemicals
RNA, Viral DNA-Directed RNA Polymerases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jennings P A
Finch J T
Winter G
Robertson J S
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/0092-8674(83)90394-x
Published
1983-09-00
Pages
619-27
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Databases
GENBANK
K00843, K00844, K00845, K00846, K00847, K00848, K00849, K00850, K00851, K00852, K00853, K00854, K00855, K00856, K00857, K00858, K00859, K00860, K00861, K00862, K00863, K00864, K00865, K00866, K00867, K00868, K00869, K00870, K00871, K00872, K00873, K00874, K00875, K00876, K00877
External Links
PubMed source DOI: 10.1016/0092-8674(83)90394-x View journal details
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