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PMID: 6641716 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.

The EMBO journal ·Vol. 2 ·No. 6 ·1983-00-00 ·Pages 1009-14

Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW

Abstract

The three-dimensional structure of sheep liver 6-phosphogluconate dehydrogenase has been determined at 2.6 A resolution by X-ray crystallographic studies. The amino acid sequence of the enzyme is now known and can be fitted to a modified electron density map. Use of 6 A electron density maps and the results of chemical modification experiments allows description of the active site and identification of residues which may be implicated in the binding of co-enzyme and substrate.

MeSH Terms
Animals Binding Sites Electrons Liver/enzymology Phosphogluconate Dehydrogenase/metabolism Protein Conformation Sheep
Chemicals
Phosphogluconate Dehydrogenase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Adams M J
Archibald I G
Bugg C E
Carne A
Gover S
Helliwell J R
Pickersgill R W
White S W
References (18)
18 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1983-00-00
Pages
1009-14
Language
English
Region
England
NLM ID
8208664
PMCID
PMC555222
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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