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PMID: 6654387 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunological responses to fed protein antigens in mice. IV. Effects of stimulating the reticuloendothelial system on oral tolerance and intestinal immunity to ovalbumin.

Immunology ·Vol. 50 ·No. 4 ·1983-12-00 ·Pages 547-54

Mowat AM, Parrot DM

Abstract

We have studied the role of the reticuloendothelial system (RES) in intestinal and systemic immunity in mice immunized orally with ovalbumin (OVA). Stimulation of the RES by oestradiol completely prevented the induction of systemic tolerance normally found in mice fed 25 mg OVA and this applied both to humoral immunity and delayed-type hypersensitivity (DTH). In addition, an active DTH response could be detected in the mucosa and mesenteric lymph nodes (MLN) of oestradiol-treated, OVA-fed mice on oral challenge with OVA. Oestradiol had no direct effect on lymphocyte function and we propose that RES activation may be one mechanism which predisposes to small intestinal disease associated with food hypersensitivity.

MeSH Terms

Administration, Oral Animals Antigens/administration & dosage,immunology Estradiol/pharmacology Hypersensitivity, Delayed Immune Tolerance/drug effects Intestinal Mucosa/immunology Intestines/immunology Lymph Nodes/immunology Male Mesentery Mice Mice, Inbred BALB C Mononuclear Phagocyte System/drug effects,immunology Ovalbumin/administration & dosage,immunology

Chemicals

Antigens Estradiol Ovalbumin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mowat A M

Parrot D M

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24 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1983-12-00

Pages

547-54

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1454385

Subset

External Links

PubMed source PMC Full Text View journal details

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Immunological responses to fed protein antigens in mice. IV. Effects of stimulating the reticuloendothelial system on oral tolerance and intestinal immunity to ovalbumin.

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