The pseudouridine contents of the ribosomal ribonucleic acids of three vertebrate species. Numerical correspondence between pseudouridine residues and 2'-O-methyl groups is not always conserved.

The Biochemical journal ·Vol. 171 ·No. 3 ·1978-06-01 ·Pages 781-6

Hughes DG, Maden BE

Abstract

The pseudouridine contents of the rRNA species of HeLa cells, mouse L-cells and Xenopus laevis cultured kidney cells were examined. Pseudouridine, like 2'-O-methylation, was found to occur relatively frequently in each of the high-molecular-weight rRNA species. However, the numerical data do not support the idea that there is a general one-to-one relationship between pseudoridine residues and 2'-O-methyl groups in vertebrate rRNA.

MeSH Terms

Animals Cells, Cultured Chemical Phenomena Chemistry Chromatography, Paper HeLa Cells/analysis Humans L Cells/analysis Methylation Mice Pseudouridine/analysis RNA, Ribosomal/analysis Uridine/analogs & derivatives Xenopus

Chemicals

RNA, Ribosomal Pseudouridine Uridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hughes D G

Maden B E

References (29)

29 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1710781

Published

1978-06-01

Pages

781-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1184027

Subset

External Links

PubMed source DOI: 10.1042/bj1710781 PMC Full Text View journal details

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The pseudouridine contents of the ribosomal ribonucleic acids of three vertebrate species. Numerical correspondence between pseudouridine residues and 2'-O-methyl groups is not always conserved.

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