Use of statistical criteria for screening potential homologies in nucleic acid sequences.

Nucleic acids research ·Vol. 12 ·No. 1 Pt 1 ·1984-01-11 ·Pages 203-13

Kanehisa M

Abstract

We proposed a simple formula to assess the statistical significance of homologous segments found in comparison of two nucleic acid sequences (Goad and Kanehisa, Nucleic Acids Res. 10, 247-263, 1982). This paper clarifies the basic assumptions of the formula and its reliability is examined by Monte Carlo calculations. The results were satisfactory for random sequences. The formula is a useful measure for screening potentially interesting homologies and it can be implemented in any search algorithms. Examples are given for the screening procedure in the graphic display version of the Goad-Kanehisa algorithm.

MeSH Terms

Base Sequence DNA, Viral Information Systems Nucleic Acids Statistics as Topic

Chemicals

DNA, Viral Nucleic Acids

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kanehisa M

References (11)

11 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/12.1part1.203

Published

1984-01-11

Pages

203-13

Language

English

Region

England

NLM ID

0411011

PMCID

PMC320997

Subset

External Links

PubMed source DOI: 10.1093/nar/12.1part1.203 PMC Full Text View journal details

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