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PMID: 6696048 Published · ppublish English Comparative Study Journal Article

Ultrastructural alterations in the atrial myocardium of pigs with acute monensin toxicosis.

The American journal of pathology ·Vol. 114 ·No. 3 ·1984-03-00 ·Pages 367-79

Van Vleet JF, Ferrans VJ

Abstract

Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atrial lesions. On days 1-4, extensive necrosis with contraction bands was present. Rapid macrophagic invasion and phagocytosis of sarcoplasmic debris was seen on days 2 and 4. Missing necrotic myocytes were outlined by persistent "tubes" of external laminas. In some surviving myocytes, sublethal injury was evident on day 1 by mitochondria with condensed conformation and on days 2, 4, and 16 by moderate to marked myofibrillar lysis and sarcoplasmic vacuolation. Monensin cardiotoxicity in pigs constitutes a unique example of selective injury to atrial myocardium.

MeSH Terms
Acute Disease Animals Cardiomyopathies/chemically induced,pathology,physiopathology Cattle Dose-Response Relationship, Drug Female Furans/toxicity Heart Atria/drug effects,pathology,ultrastructure Macrophages/pathology,ultrastructure Male Monensin/toxicity Myocardial Contraction/drug effects Myocardium/pathology,ultrastructure Necrosis Swine
Chemicals
Furans Monensin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Van Vleet J F
Ferrans V J
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1984-03-00
Pages
367-79
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1900426
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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