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PMID: 6696523 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mast cells at sites of cartilage erosion in the rheumatoid joint.

Annals of the rheumatic diseases ·Vol. 43 ·No. 1 ·1984-02-00 ·Pages 76-9

Bromley M, Fisher WD, Woolley DE

Abstract

Cartilage-pannus junctions of the rheumatoid lesion have been examined by histochemical and ultrastructural techniques in an attempt to identify the cells responsible for cartilage degradation. Mast cells have been identified at sites of cartilage erosion in 3 specimens of rheumatoid joint. It is known that mast cells participate in immunological reactions, produce the vasoactive and proteinase-modulating agents histamine and heparin as well as their own degradative proteinases. The close association of mast cells with sites of cartilage erosion suggests they may play an important role in the pathophysiology of joint destruction in rheumatoid arthritis.

MeSH Terms
Arthritis, Rheumatoid/pathology Cartilage, Articular/pathology,ultrastructure Humans Mast Cells/pathology,ultrastructure Microscopy, Electron
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bromley M
Fisher W D
Woolley D E
References (20)
20 references, click to expand
  1. Cytochemical identification of monocytes and granulocytes.
    Am J Clin Pathol. 1971 Mar;55(3):283-90 PMID: 5549896
  2. The microscopic structure of normal human synovial tissue.
    Arthritis Rheum. 1960 Apr;3:140-51 PMID: 13808324
  3. Histochemical characterization of cellular and structural elements of the human spleen.
    J Histochem Cytochem. 1972 Dec;20(12):1049-58 PMID: 4118358
  4. Studies on the interaction between heparin and mouse bone collagenase.
    Biochim Biophys Acta. 1975 Mar 14;385(1):41-50 PMID: 164924
  5. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis.
    Arthritis Rheum. 1975 Sep-Oct;18(5):475-83 PMID: 1191348
  6. Collagenase at sites of cartilage erosion in the rheumatoid joint.
    Arthritis Rheum. 1977 Jul-Aug;20(6):1231-9 PMID: 71152
  7. The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis.
    Z Rheumatol. 1978 Mar-Apr;37(3-4):81-6 PMID: 636668
  8. Light- and electron-microscopic findings of juvenile rheumatoid arthritis synovium: comparison with normal juvenile synovium.
    Semin Arthritis Rheum. 1978 May;7(4):287-302 PMID: 644340
  9. Homeostasis of effector systems which can also be recruited for immunologic reactions.
    J Immunol. 1978 Sep;121(3):793-805 PMID: 357653
  10. Collagenase, procollagenase and bone resorption. Effects of heparin, parathyroid hormone and calcitonin.
    Biochim Biophys Acta. 1979 May 16;584(3):375-88 PMID: 222339
  11. Biologic implications of the structural and functional characteristics of the chemical mediators of immediate-type hypersensitivity.
    Harvey Lect. 1979;73:93-161 PMID: 396278
  12. Enzymes of the mast cell granule.
    J Invest Dermatol. 1980 May;74(5):349-53 PMID: 6771334
  13. Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue.
    Z Rheumatol. 1980 May-Jun;39(5-6):145-56 PMID: 6998181
  14. Polymorphonuclear granulocytes at the pannus-cartilage junction in rheumatoid arthritis.
    Arthritis Rheum. 1980 Dec;23(12):1413-14 PMID: 7458978
  15. Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds.
    Nature. 1981 Sep 10-16;293(5828):103-8 PMID: 6115319
  16. Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine.
    Allergy. 1981 Aug;36(6):435-6 PMID: 6172050
  17. Protamine is an inhibitor of angiogenesis.
    Nature. 1982 May 27;297(5864):307-12 PMID: 6176876
  18. Mast cells in connective tissue diseases.
    Arthritis Rheum. 1958 Apr;1(2):178-80 PMID: 13535314
  19. FINE STRUCTURES OF THE SYNOVIAL TISSUES IN RHEUMATOID ARTHRITIS.
    Kobe J Med Sci. 1964 Dec;10:195-225 PMID: 14291103
  20. The mast cell in early rat adjuvant arthritis.
    Ann Rheum Dis. 1971 Jan;30(1):24-30 PMID: 5554508
Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.43.1.76
Published
1984-02-00
Pages
76-9
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1001227
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.43.1.76 PMC Full Text View journal details
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