Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).

International journal of peptide and protein research ·Vol. 11 ·No. 4 ·1978-04-00 ·Pages 289-96

Lefrancier P, Derrien M, Lederman I, Nief F, Choay J, Lederer E

Abstract

In our continued efforts to elucidate the relationship between the structure and the immunoadjuvant, antiinfectious or mitogenic activity of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), we report the synthesis of 11 new analogs. Five of them present some modifications in the N-acetyl-muramyl moiety.

MeSH Terms

Adjuvants, Immunologic/chemical synthesis Amino Acid Sequence Anti-Infective Agents/pharmacology Glycopeptides/chemical synthesis,pharmacology Mitogens/pharmacology

Chemicals

Adjuvants, Immunologic Anti-Infective Agents Glycopeptides Mitogens

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Lefrancier P

Derrien M

Lederman I

Nief F

Choay J

Lederer E

Article Info

Journal

International journal of peptide and protein research

Abbr.

Int J Pept Protein Res

ISSN

0367-8377

DOI

10.1111/j.1399-3011.1978.tb02851.x

Published

1978-04-00

Pages

289-96

Language

English

Region

Denmark

NLM ID

0330420

Subset

External Links

PubMed source DOI: 10.1111/j.1399-3011.1978.tb02851.x

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Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).

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