Effect of inoculum, pH, and medium on the activity of ciprofloxacin against anaerobic bacteria.

Antimicrobial agents and chemotherapy ·Vol. 25 ·No. 3 ·1984-03-00 ·Pages 342-3

Borobio MV, Perea EJ

Abstract

The in vitro activity of ciprofloxacin against 30 Bacteroides fragilis group, 30 Clostridium, and 30 Peptococcaceae strains was determined by the agar dilution method in two different culture media at three pH and in three inoculum densities. In Wilkins-Chalgren agar the MICs for 90% of the strains were 0.12 micrograms/ml for B. fragilis, 0.5 micrograms/ml for Clostridium spp., and 2 micrograms/ml for Peptococcaceae. The pH and medium composition affected the MICs of ciprofloxacin.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacteria, Anaerobic/drug effects Bacteroides fragilis/drug effects Ciprofloxacin Clostridium/drug effects Culture Media/pharmacology Hydrogen-Ion Concentration Metronidazole/pharmacology Microbial Sensitivity Tests Peptococcaceae/drug effects Quinolines/pharmacology

Chemicals

Anti-Bacterial Agents Culture Media Quinolines Metronidazole Ciprofloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Borobio M V

Perea E J

References (8)

8 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.25.3.342

Published

1984-03-00

Pages

342-3

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC185513

Subset

External Links

PubMed source DOI: 10.1128/AAC.25.3.342 PMC Full Text View journal details

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Effect of inoculum, pH, and medium on the activity of ciprofloxacin against anaerobic bacteria.

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