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PMID: 672957
Published · ppublish
English
Journal Article
Where do general anaesthetics act?
Abstract
General anaesthetics were found to have no effect on lipid bilayer structures when studied using X-ray and neutron diffraction. Combined gaseous and aqueous phase solubility data suggested that the primary site of action of general anaesthetics has both polar and nonpolar characteristics, and probably involves protein.
MeSH Terms
Anesthetics/pharmacology
Chemical Phenomena
Chemistry, Physical
Cholesterol
Gases
Membrane Proteins
Membranes, Artificial
Neutrons
Oils
Phosphatidylcholines
Scattering, Radiation
Solubility
Water
X-Ray Diffraction
Chemicals
Anesthetics
Gases
Membrane Proteins
Membranes, Artificial
Oils
Phosphatidylcholines
Water
Cholesterol
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1978-07-27
Pages
339-42
Language
English
Region
England
NLM ID
0410462
Subset
IM
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