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PMID: 6732796 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Extracellular calcium protects isolated rat hepatocytes from injury.

Biochemical and biophysical research communications ·Vol. 121 ·No. 1 ·1984-05-31 ·Pages 102-10

Fariss MW, Olafsdottir K, Reed DJ

Abstract

The incubation of isolated rat hepatocytes in calcium-free medium resulted in a pronounced increase in lipid peroxidation, mitochondrial and cytoplasmic glutathione depletion, glutathione disulfide formation and efflux of reduced glutathione as compared with hepatocytes incubated in calcium containing medium. These data suggest that extracellular calcium ions serve a protective role in isolated rat hepatocytes against cell injury.

MeSH Terms

Animals Calcium/physiology Extracellular Space/metabolism Glutathione/analogs & derivatives,biosynthesis,metabolism Glutathione Disulfide In Vitro Techniques L-Lactate Dehydrogenase/metabolism Lipid Peroxides/biosynthesis Liver/drug effects,metabolism,ultrastructure Potassium/metabolism Rats

Chemicals

Lipid Peroxides L-Lactate Dehydrogenase Glutathione Potassium Calcium Glutathione Disulfide

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fariss M W

Olafsdottir K

Reed D J

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/0006-291x(84)90693-4

Published

1984-05-31

Pages

102-10

Language

English

Region

United States

NLM ID

0372516

Subset

Grants

NIEHS NIH HHS · ES01978 · United States

NIEHS NIH HHS · ES07060 · United States

External Links

PubMed source DOI: 10.1016/0006-291x(84)90693-4 View journal details

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Extracellular calcium protects isolated rat hepatocytes from injury.

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