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PMID: 6735470 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.

Infection and immunity ·Vol. 45 ·No. 1 ·1984-07-00 ·Pages 293-6

Kotani S, Takada H, Tsujimoto M, Ogawa T, Harada K, Mori Y, Kawasaki A, Tanaka A, Nagao S, Tanaka S

Abstract

Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzman induction activity of the synthetic analogs, however, were much less than those of natural lipid A.

MeSH Terms

Adult Animals Complement System Proteins/immunology Guinea Pigs Horseshoe Crabs Humans Lipid A/analogs & derivatives,chemical synthesis,toxicity Lymphocyte Activation Lymphocytes/drug effects,immunology Macrophage Activation Macrophages/drug effects,immunology Mice Structure-Activity Relationship

Chemicals

Lipid A Complement System Proteins

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Kotani S

Takada H

Tsujimoto M

Ogawa T

Harada K

Mori Y

Kawasaki A

Tanaka A

Nagao S

Tanaka S

References (11)

11 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.45.1.293-296.1984

Published

1984-07-00

Pages

293-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC263318

Subset

External Links

PubMed source DOI: 10.1128/iai.45.1.293-296.1984 PMC Full Text View journal details

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Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.

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