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PMID: 6742831 Published · ppublish English Journal Article

Absence of transformation of beta-muricholic acid by human microflora implanted in the digestive tracts of germfree male rats.

Applied and environmental microbiology ·Vol. 47 ·No. 5 ·1984-05-00 ·Pages 1167-8

Sacquet EC, Gadelle DP, Riottot MJ, Raibaud PM

Abstract

Germfree rats biosynthetize cholic and beta-muricholic acids. The latter does not exist in humans. Germfree rats were given human fecal suspensions. These rats degraded cholic acid into deoxycholic acid but failed to metabolize beta-muricholic acid.

MeSH Terms
Animals Bacteria/metabolism Biotransformation Cholic Acid Cholic Acids/metabolism Chromatography, Gas Deoxycholic Acid/biosynthesis Digestive System/metabolism,microbiology Feces/microbiology Female Germ-Free Life Humans Male Rats
Chemicals
Cholic Acids Deoxycholic Acid muricholic acid hyodeoxycholic acid Cholic Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sacquet E C
Gadelle D P
Riottot M J
Raibaud P M
References (4)
4 references, click to expand
  1. Fecal neutral steroids and bile acids from germfree rats.
    J Lipid Res. 1969 Sep;10(5):495-503 PMID: 5808824
  2. Bile acids. 28. Gas chromatography of new bile acids and their derivatives.
    J Chromatogr. 1969 Nov 11;44(3):452-64 PMID: 5356710
  3. Implantation of bacteria from the digestive tract of man and various animals into gnotobiotic mice.
    Am J Clin Nutr. 1980 Nov;33(11 Suppl):2440-7 PMID: 7001883
  4. QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL FECAL BILE ACIDS.
    J Lipid Res. 1965 Jul;6:397-410 PMID: 14336211
Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
DOI
10.1128/aem.47.5.1167-1168.1984
Published
1984-05-00
Pages
1167-8
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC240096
Subset
IM
External Links
PubMed source DOI: 10.1128/aem.47.5.1167-1168.1984 PMC Full Text View journal details
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