Home LiteratureArticle Details
PMID: 6745944 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Prenatal identification of a deleted Y chromosome by cytogenetics and a Y-specific repetitive DNA probe.

Human genetics ·Vol. 67 ·No. 2 ·1984-00-00 ·Pages 222-4

Disteche C, Luthy D, Haslam DB, Hoar D

Abstract

A very small sex chromosome was identified prenatally as a Y chromosome by using molecular hybridization in conjunction with conventional cytogenetics techniques. The combination of R-banding, Q-banding, distamycin-DAPI staining suggested that the chromosome might be a de novo deletion of the Y chromosome as the father's Y chromosome was normal. Restriction enzyme analysis of amniotic fluid cell DNA using a Y chromosome repetitive probe confirmed the origin of this chromosome.

MeSH Terms
Adult Amniotic Fluid/analysis Chromosome Banding Chromosome Deletion DNA/analysis Female Humans Infant, Newborn Male Pregnancy Prenatal Diagnosis Sex Chromosome Aberrations/diagnosis Y Chromosome
Chemicals
DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Disteche C
Luthy D
Haslam D B
Hoar D
References (14)
14 references, click to expand
  1. A simple method for R banding of human chromosomes, showing a pH-dependent connection between R and G bands.
    Humangenetik. 1974 Jan 22;21(1):55-8 PMID: 4134931
  2. Confirmation of Y/autosome translocation using recombinant DNA.
    Hum Genet. 1979;50(1):39-44 PMID: 468259
  3. Regional assignment of a 2.1-kb repetitive sequence to the distal part of the human Y heterochromatin.
    Hum Genet. 1980;55(2):255-7 PMID: 7450768
  4. Improved direct molecular diagnosis and rapid fetal sexing.
    Prenat Diagn. 1984 Jul-Aug;4(4):241-7 PMID: 6483785
  5. Repeated sequence specific to human males.
    Nature. 1976 Jul 15;262(5565):182-6 PMID: 819844
  6. Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes.
    Proc Natl Acad Sci U S A. 1982 Sep;79(17):5352-6 PMID: 6291041
  7. Characterization of a new aberration of the human Y chromosome by banding methods and DNA restriction endonuclease analysis.
    Hum Genet. 1981;59(1):26-35 PMID: 10819018
  8. A synopsis of the human Y chromosome.
    Hum Genet. 1980;55(2):145-75 PMID: 7005073
  9. Identification of human chromosomes by DNA-binding fluorescent agents.
    Chromosoma. 1970;30(2):215-27 PMID: 4193398
  10. Quinacrine fluorescence of the human Y chromosome.
    Nature. 1971 Mar 5;230(5288):52 PMID: 4102824
  11. Modification of DAPI banding on human chromosomes by prestaining with a DNA-binding oligopeptide antibiotic, distamycin A.
    Exp Cell Res. 1978 Feb;111(2):327-32 PMID: 75107
  12. Human amniotic fluid cells grown in a hormone-supplemented medium: suitability for prenatal diagnosis.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4795-9 PMID: 6956891
  13. Nonfluorescent Y chromosomes. Cytologic evidence of origin.
    Hum Genet. 1982;60(2):133-8 PMID: 7076253
  14. Enduclease analysis of Y chromosome DNA.
    Cytogenet Cell Genet. 1978;22(1-6):357-8 PMID: 752502
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00273007
Published
1984-00-00
Pages
222-4
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
NIA NIH HHS · AG 01751 · United States
External Links
PubMed source DOI: 10.1007/BF00273007 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2