Comparison of virulence and colonizing capacity of Escherichia coli K1 and non-K1 strains in neonatal rats.

Infection and immunity ·Vol. 37 ·No. 2 ·1982-08-00 ·Pages 830-2

Scannapieco FA, Guerina NG, Goldmann DA

Abstract

Neonatal rats fed three strains of Escherichia coli K1 at birth had bacteremia rates of 29 to 81%; negligible bacteremia was seen with K92 and an unencapsulated strain. Despite this marked difference in virulence, K1, K92, and the unencapsulated strain all promptly, reliably, and stably colonized the entire alimentary tract, from pharynx to colon.

MeSH Terms

Animals Animals, Newborn Antigens Antigens, Bacterial Antigens, Surface Digestive System/microbiology Escherichia coli/classification,growth & development,pathogenicity Escherichia coli Infections/complications,microbiology,mortality Intestines/microbiology Oropharynx/microbiology Rats Rats, Inbred Strains Sepsis/etiology,microbiology Virulence

Chemicals

Antigens Antigens, Bacterial Antigens, Surface K antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Scannapieco F A

Guerina N G

Goldmann D A

References (5)

5 references, click to expand

Dynamics of Escherichia coli infection and meningitis in infant rats.
Infect Immun. 1978 Nov;22(2):480-5 PMID: 365760
Model of neonatal meningitis caused by Escherichia coli K1 in guinea pigs.
J Infect Dis. 1980 Feb;141(2):193-7 PMID: 6988521
Pathogenesis of neonatal Escherichia coli meningitis: induction of bacteremia and meningitis in infant rats fed E. coli K1.
Infect Immun. 1977 Apr;16(1):75-80 PMID: 326679
Relation between Escherichia coli K1 capsular polysaccharide antigen and clinical outcome in neonatal meningitis.
Lancet. 1974 Aug 3;2(7875):246-50 PMID: 4136144
Escherichia coli K1 capsular polysaccharide associated with neonatal meningitis.
N Engl J Med. 1974 May 30;290(22):1216-20 PMID: 4133095

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.37.2.830-832.1982

Published

1982-08-00

Pages

830-2

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347606

Subset

External Links

PubMed source DOI: 10.1128/iai.37.2.830-832.1982 PMC Full Text View journal details

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Comparison of virulence and colonizing capacity of Escherichia coli K1 and non-K1 strains in neonatal rats.

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