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PMID: 6751906 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment.

Diabetologia ·Vol. 23 ·No. 3 ·1982-09-00 ·Pages 266-9

Risteli J, Draeger KE, Regitz G, Neubauer HP

Abstract

The serum concentrations of two recently discovered antigens derived from basement membranes (7-S collagen and laminin P2) were assayed in streptozotocin-diabetic rats as possible indicators of basement membrane metabolism. The concentrations of both increased significantly after 8 weeks of diabetes, and that of 7-S collagen at least remained elevated up to 24 weeks. Treatment with insulin, which did not correct the metabolic disturbances, inhibited the increase in the concentration of 7-S collagen in serum, but did not completely normalize that of laminin P2.

MeSH Terms
Animals Antigens/analysis Basement Membrane/immunology Blood Glucose/analysis Collagen/immunology Diabetes Mellitus, Experimental/blood,drug therapy,immunology Glycoproteins/immunology Insulin/therapeutic use Laminin Male Rats Rats, Inbred Strains
Chemicals
Antigens Blood Glucose Glycoproteins Insulin Laminin Collagen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Risteli J
Draeger K E
Regitz G
Neubauer H P
References (13)
13 references, click to expand
  1. Basement membrane research.
    Med Biol. 1981 Aug;59(4):185-9 PMID: 7339293
  2. Macromolecular structure of basement membrane collagens.
    FEBS Lett. 1981 Mar 9;125(1):123-8 PMID: 6262125
  3. Immunological characterization of the 7-S domain of type IV collagens.
    Coll Relat Res. 1981 Sep;1(5):419-32 PMID: 6809413
  4. Laminin--a glycoprotein from basement membranes.
    J Biol Chem. 1979 Oct 10;254(19):9933-7 PMID: 114518
  5. Sensitive radioimmunoassays for 7 S collagen and laminin: application to serum and tissue studies of basement membranes.
    Anal Biochem. 1981 May 15;113(2):372-8 PMID: 7283141
  6. Isolation and characterization of pepsin fragments of laminin from human placental and renal basement membranes.
    Biochem J. 1981 Mar 1;193(3):749-55 PMID: 6796051
  7. Type IV collagens' isolation and characterization of 7S collagen from human kidney, liver and lung.
    Coll Relat Res. 1981 Nov;1(6):549-56 PMID: 6286238
  8. Laboratory animals exhibiting obesity and diabetes syndromes.
    Metabolism. 1977 Jan;26(1):59-99 PMID: 834144
  9. Characterization of pepsin fragments of laminin in a tumor basement membrane. Evidence for the existence of related proteins.
    Hoppe Seylers Z Physiol Chem. 1980 Nov;361(11):1651-60 PMID: 6778807
  10. Current status of capillary basement-membrane disease in diabetes mellitus.
    Diabetes. 1977 Jan;26(1):65-73 PMID: 318626
  11. Some statistical methods useful in circulation research.
    Circ Res. 1980 Jul;47(1):1-9 PMID: 7379260
  12. Blood sugar and the complications of diabetes.
    Science. 1979 Mar 16;203(4385):1098-9 PMID: 424736
  13. 7-S collagen: characterization of an unusual basement membrane structure.
    Eur J Biochem. 1980;108(1):239-50 PMID: 6250829
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00252853
Published
1982-09-00
Pages
266-9
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00252853 View journal details
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