Nonenzymatic chloramphenicol resistance determinants specified by plasmids R26 and R55-1 in Escherichia coli K-12 do not confer high-level resistance to fluorinated analogs.

Antimicrobial agents and chemotherapy ·Vol. 22 ·No. 5 ·1982-11-00 ·Pages 912-4

Dorman CJ, Foster TJ

Abstract

Plasmids R26 (Inc P) and R55-1 (Inc C) specify inducible nonenzymatic resistance to chloramphenicol. Escherichia coli K-12 strains harboring these plasmids encoded low-level resistance to thiamphenicol analogs Sch 25298 and Sch 25393 but failed to specify resistance to the fluorinated chloramphenicol analog Sch 24893. The analogs were efficient inducers of high-level chloramphenicol resistance.

MeSH Terms

Chloramphenicol/analogs & derivatives,pharmacology Drug Resistance, Microbial Escherichia coli/drug effects,genetics R Factors Thiamphenicol/analogs & derivatives,pharmacology

Chemicals

Chloramphenicol Sch 25393 3-fluorochloramphenicol florfenicol Thiamphenicol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dorman C J

Foster T J

References (8)

8 references, click to expand

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New type of R factors incapable of inactivating chloramphenicol.
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Incompatibility groups and the classification of fi - resistance factors.
J Bacteriol. 1972 Nov;112(2):666-75 PMID: 4628744
Phenotypic characterization of R-factor tetracycline resistance determinants.
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A molecular analysis of transductional marker rescue involving P-group plasmids in Pseudomonas aeruginosa.
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Mechanism of chloramphenicol-resistance mediated by kR102 factor in Pseudomonas aeruginosa.
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Chloramphenicol resistance that does not involve chloramphenicol acetyltransferase encoded by plasmids from gram-negative bacteria.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.22.5.912

Published

1982-11-00

Pages

912-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC185684

Subset

External Links

PubMed source DOI: 10.1128/AAC.22.5.912 PMC Full Text View journal details

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Nonenzymatic chloramphenicol resistance determinants specified by plasmids R26 and R55-1 in Escherichia coli K-12 do not confer high-level resistance to fluorinated analogs.

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