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PMID: 6770464 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.

Science (New York, N.Y.) ·Vol. 208 ·No. 4451 ·1980-06-27 ·Pages 1473-5

Dees JH, Coe LD, Yasukochi Y, Masters BS

Abstract

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.

MeSH Terms

Animals Fluorescent Antibody Technique Kidney/drug effects,enzymology Liver/drug effects,enzymology Lung/drug effects,enzymology Male NADPH-Ferrihemoprotein Reductase/metabolism Organ Specificity Phenobarbital/pharmacology Rats

Chemicals

NADPH-Ferrihemoprotein Reductase Phenobarbital

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Dees J H

Coe L D

Yasukochi Y

Masters B S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6770464

Published

1980-06-27

Pages

1473-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6770464 View journal details

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Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.

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