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PMID: 6770465 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Prolongation of islet xenograft survival without continuous immunosuppression.

Science (New York, N.Y.) ·Vol. 209 ·No. 4453 ·1980-07-11 ·Pages 283-5

Lacy PE, Davie JM, Finke EH

Abstract

The survival of isolated rat islets transplanted into diabetic mice was prolonged markedly by maintaining the rat islets in vitro at 24 degrees C for 7 days before transplantation and administering to the recipients a single injection of antiserum to mouse and rat lymphocytes shortly before transplantation.

MeSH Terms
Animals Blood Glucose/analysis Cell Survival Cells, Cultured Diabetes Mellitus, Experimental/therapy Immunosuppression Therapy Islets of Langerhans Transplantation Lymphocytes/immunology Male Mice Mice, Inbred BALB C Rats Transplantation, Heterologous Transplantation, Isogeneic
Chemicals
Blood Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lacy P E
Davie J M
Finke E H
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1980-07-11
Pages
283-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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