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PMID: 6770958 Published · ppublish English Journal Article

Prolonged use of the Greenland method of treatment of gonorrhoea.

The British journal of venereal diseases ·Vol. 56 ·No. 2 ·1980-04-00 ·Pages 88-91

Evans AJ, Morrison GD, Price DJ

Abstract

Of 1081 patients with gonorrhoea treated with probenecid 1 g orally and benzyl penicillin 5 megaunits intramuscularly, 96.7% were cured and no complications were encountered. This treatment regimen was associated with a pronounced reduction in the proportion of gonococcal strains showing diminished sensitivity to penicillin, from 51% to between 4% and 14% over a period of four years. When this treatment method was abandoned, however, the percentage of less sensitive strains rose to 33% over the following 18 months.

MeSH Terms
Drug Therapy, Combination Female Gonorrhea/drug therapy Humans Male Neisseria gonorrhoeae/drug effects Penicillin G/administration & dosage,therapeutic use Penicillin Resistance Penicillins/pharmacology Probenecid/administration & dosage,therapeutic use Species Specificity
Chemicals
Penicillins Probenecid Penicillin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Evans A J
Morrison G D
Price D J
References (10)
10 references, click to expand
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    Br J Vener Dis. 1966 Jun;42(2):107-9 PMID: 5947596
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    Br J Vener Dis. 1972 Jun;48(3):179-81 PMID: 4627048
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    N Engl J Med. 1976 Jan 1;294(1):5-9 PMID: 127947
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    Br J Vener Dis. 1958 Jun;34(2):70-8; discussion 78-82 PMID: 13560791
  6. Single-session treatment of uncomplicated gonorrhoea in men, using penicillin combined with cotrimoxazole. Controlled trial comparing four different treatment schedules with observations on antibiotic sensitivities of gonococci and a review of the literature.
    Br J Vener Dis. 1973 Jun;49(3):277-90 PMID: 4578213
  7. Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid.
    Br J Vener Dis. 1970 Oct;46(5):401-3 PMID: 4991033
  8. Gonorrhoea treated by a combination of probenecid and sodium penicillin G.
    Br J Vener Dis. 1969 Jun;45(2):144-8 PMID: 5787685
  9. Sensitivity of strains of gonococci to penicillin, sulphathiazole, and streptomycin.
    Br Med J. 1958 May 10;1(5079):1091-2 PMID: 13536426
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Article Info
Journal
The British journal of venereal diseases
Abbr.
Br J Vener Dis
ISSN
0007-134X
DOI
10.1136/sti.56.2.88
Published
1980-04-00
Pages
88-91
Language
English
Region
England
NLM ID
0421042
PMCID
PMC1045739
Subset
IM
External Links
PubMed source DOI: 10.1136/sti.56.2.88 PMC Full Text
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