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LiteratureArticle Details
PMID: 6774257
Published · ppublish
English
Journal Article
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing.
Abstract
The IF2 immunoglobulin mutant is a DNA deletion of one coding segment and large sections of the flanking intervening sequences. The deletion results in a new splicing pattern and starts in a DNA region containing tandemly repeated sequences which may carry heavy-chain class switch signals.
MeSH Terms
Animals
Base Sequence
Chromosome Deletion
DNA/genetics
Genes
Heavy Chain Disease/genetics
Humans
Immunoglobulin Constant Regions/genetics
Immunoglobulin Heavy Chains/genetics
Immunoglobulin gamma-Chains/genetics
Immunoglobulins/genetics
Mice
Mutation
Nucleic Acid Conformation
Nucleic Acid Precursors/genetics
RNA, Messenger/genetics
Chemicals
Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Immunoglobulin gamma-Chains
Immunoglobulins
Nucleic Acid Precursors
RNA, Messenger
DNA
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1980-08-14
Pages
669-75
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
J00542,
J00543,
K00685,
N00007
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