Home LiteratureArticle Details
PMID: 6776225 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.

The Journal of experimental medicine ·Vol. 152 ·No. 5 ·1980-11-01 ·Pages 1135-46

Zitron IM, Clevinger BL

Abstract

We describe the identification of a monoclonal antibody that recognizes a determinant on the delta chain of mice of the Iga, allotype groups. The monoclonal Ig in soluble form induces allotype-specific proliferation by splenic B lymphocytes from normal animals of these haplotypes. Spleen cells from mice bearing the X-linked defect of CBA/N mice fail to respond, although they bear the determinant. Proliferation is independent of T lymphocytes. The data indicate a direct triggering function for sIgD.

MeSH Terms
Animals B-Lymphocytes/immunology Immunoglobulin Allotypes/immunology Immunoglobulin D/immunology Immunoglobulin G/immunology Immunoglobulin Heavy Chains/immunology Immunoglobulin delta-Chains/immunology Mice Mice, Inbred Strains Receptors, Antigen, B-Cell/immunology
Chemicals
Immunoglobulin Allotypes Immunoglobulin D Immunoglobulin G Immunoglobulin Heavy Chains Immunoglobulin delta-Chains Receptors, Antigen, B-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zitron I M
Clevinger B L
References (29)
29 references, click to expand
  1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  2. The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat.
    J Immunol. 1971 Aug;107(2):481-92 PMID: 4936290
  3. The distribution of alloantigenic specificities of native H-2 products.
    J Immunol. 1972 Mar;108(3):596-600 PMID: 4110980
  4. Cloning of mouse myeloma cells and detection of rare variants.
    J Cell Physiol. 1972 Jun;79(3):429-40 PMID: 4625122
  5. Separation of mouse spleen cells by passage through columns of sephadex G-10.
    J Immunol Methods. 1974 Aug;5(3):239-47 PMID: 4610054
  6. Membrane immunoglobulins and antigen receptors on B and T lymphocytes.
    Adv Immunol. 1974;19(0):67-216 PMID: 4139885
  7. One non-specific signal triggers b lymphocytes.
    Transplant Rev. 1975;23:126-37 PMID: 1094629
  8. Continuous cultures of fused cells secreting antibody of predefined specificity.
    Nature. 1975 Aug 7;256(5517):495-7 PMID: 1172191
  9. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.
    J Immunol. 1975 Dec;115(6):1617-24 PMID: 1102604
  10. Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin.
    Nature. 1975 Nov 27;258(5533):361-3 PMID: 1081652
  11. Immunoglobulin-receptors revisited.
    Science. 1975 Sep 19;189(4207):964-9 PMID: 1083069
  12. Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response.
    J Immunol. 1976 Jun;116(6):1656-61 PMID: 58043
  13. Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.
    J Exp Med. 1977 Jan 1;145(1):10-20 PMID: 299766
  14. B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.
    J Exp Med. 1977 Jan 1;145(1):101-10 PMID: 299767
  15. Antibodies to major histocompatibility antigens produced by hybrid cell lines.
    Nature. 1977 Apr 7;266(5602):550-2 PMID: 558524
  16. The role of surface IgD in the response to thymic-independent antigens.
    J Exp Med. 1977 Dec 1;146(6):1707-18 PMID: 72781
  17. Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.
    Proc Natl Acad Sci U S A. 1978 Jan;75(1):432-5 PMID: 305047
  18. Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response.
    J Exp Med. 1978 Mar 1;147(3):814-29 PMID: 416168
  19. Control of proliferation and differentiation in B lymphocytes by anti-Ig antibodies and a serum-derived cofactor.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2401-5 PMID: 307763
  20. Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation.
    Contemp Top Immunobiol. 1978;8:203-43 PMID: 357078
  21. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.
    Curr Top Microbiol Immunol. 1978;81:115-20 PMID: 567555
  22. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.
    Immunochemistry. 1978 Jul;15(7):429-36 PMID: 30693
  23. A better cell line for making hybridomas secreting specific antibodies.
    Nature. 1978 Nov 16;276(5685):269-70 PMID: 714156
  24. The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells.
    Immunol Rev. 1979;43:69-95 PMID: 83290
  25. Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens.
    J Exp Med. 1979 Feb 1;149(2):495-506 PMID: 84046
  26. A dichotomy between the expression of IgD on B cells and its requirement for triggering such cells with two T-independent antigens.
    J Exp Med. 1979 Apr 1;149(4):987-92 PMID: 311818
  27. Preparation of an antibody to mouse serum IgD.
    J Immunol. 1979 Aug;123(2):952-4 PMID: 458161
  28. The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells.
    J Exp Med. 1979 Aug 1;150(2):256-66 PMID: 458375
  29. Membrane orientation and location of multiple and distinct allotypic determinants of mouse lymphocyte IgD.
    J Immunol. 1979 Dec;123(6):2772-8 PMID: 91644
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.152.5.1135
Published
1980-11-01
Pages
1135-46
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185997
Subset
IM
Grants
NIAID NIH HHS · AI-05599 · United States
NIAID NIH HHS · AI-15353 · United States
External Links
PubMed source DOI: 10.1084/jem.152.5.1135 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2