Home LiteratureArticle Details
PMID: 6779306 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of 5-hydroxytryptamine and noradrenaline uptake in platelets and synaptosomes incubated in plasma from human subjects treated with amitryptyline or nortriptyline: utilization of the principle for a bioassay method.

Psychopharmacology ·Vol. 69 ·No. 2 ·1980-00-00 ·Pages 137-42

Tuomisto J, Tukiainen E, Voutilainen R, Tuomainen P

Abstract

暂无摘要

MeSH Terms
Adult Amitriptyline/analysis,pharmacology Animals Antidepressive Agents, Tricyclic/analysis,pharmacology Biological Assay Blood Platelets/metabolism Humans Norepinephrine/metabolism Nortriptyline/analysis,pharmacology Rats Serotonin/metabolism Synaptosomes/metabolism
Chemicals
Antidepressive Agents, Tricyclic Amitriptyline Serotonin Nortriptyline Norepinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tuomisto J
Tukiainen E
Voutilainen R
Tuomainen P
References (13)
13 references, click to expand
  1. No circadian effect on nortriptyline kinetics in man.
    Clin Pharmacol Ther. 1978 Feb;23(2):199-203 PMID: 620481
  2. Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity.
    Biol Psychiatry. 1979 Aug;14(4):601-13 PMID: 486616
  3. Pharmacological and biochemical studies with three metabolites of nomifensine.
    Psychopharmacology (Berl). 1977 Jan 31;51(2):117-23 PMID: 402662
  4. The uptake of adrenaline and noradrenaline by blood platelets of the pig.
    Br J Pharmacol Chemother. 1958 Dec;13(4):411-4 PMID: 13618545
  5. Plasma nortriptyline and clinical response.
    Clin Pharmacol Ther. 1974 Oct;16(4):639-44 PMID: 4608523
  6. The human platelet as a pharmacologic model for the adrenergic neuron. The uptake and release of norepinephrine.
    Clin Pharmacol Ther. 1969 Sep-Oct;10(5):702-9 PMID: 4390109
  7. 5-Hydroxytryptamine and dopamine transport by rat and human blood platelets.
    Br J Pharmacol. 1978 Feb;62(2):219-26 PMID: 623937
  8. Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain.
    Life Sci. 1979 Jan 1;24(1):21-8 PMID: 763066
  9. Gas chromatography-mass spectrometry of nortriptyline in body fluids of man.
    Clin Pharmacol Ther. 1971 May-Jun;12(3):496-505 PMID: 5571282
  10. Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression.
    Psychopharmacology (Berl). 1979 Oct;65(2):141-7 PMID: 117482
  11. The role of plasma protein binding in the inhibitory effect of nortriptyline on the neuronal uptake of norepinephrine.
    Clin Pharmacol Ther. 1970 Jul-Aug;11(4):581-8 PMID: 5429182
  12. Nortriptyline and 10-hydroxynortriptyline plasma concentrations.
    J Pharm Pharmacol. 1976 Nov;28(11):849-50 PMID: 11300
  13. The accumulation of dopamine into striatal synaptosomes, and its inhibition: comparison of crude, partially purified and purified synaptosomal preparations.
    Med Biol. 1979 Aug;57(4):238-45 PMID: 513880
Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00427639
Published
1980-00-00
Pages
137-42
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00427639 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2