[A new synthetic antibacterial : 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1, 4-dihydroquinolin-3-carboxylic acid (1589 R.B.)].

Sur un nouvel antibactérien de synthèse : l'acide éthyl-1 fluoro-6 (méthyl-4 pipérazinyl-1)-7 oxo-4 dihydro-1.4 quinoléine-3 carboxylique (1589 R.B.).

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie ·Vol. 292 ·No. 1 ·1981-01-05 ·Pages 37-40

Goueffon Y, Montay G, Roquet F, Pesson M

Abstract

The 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxoquinoline- 3-carboxylic acid (1589 R.B.) is a broad antibacterial agent active in experimental infections. The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.

MeSH Terms

Administration, Oral Animals Anti-Bacterial Agents/metabolism,pharmacology Bacteria/drug effects Dogs Humans Injections, Intraperitoneal Injections, Intravenous Lethal Dose 50 Mice Pefloxacin Quinolines/metabolism,pharmacology Rats

Chemicals

Anti-Bacterial Agents Quinolines Pefloxacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Goueffon Y

Montay G

Roquet F

Pesson M

Article Info

Journal

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

Abbr.

C R Seances Acad Sci III

ISSN

0249-6313

Published

1981-01-05

Pages

37-40

Language

fre

Region

France

NLM ID

8108553

Subset

External Links

PubMed source

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[A new synthetic antibacterial : 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1, 4-dihydroquinolin-3-carboxylic acid (1589 R.B.)].

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