Home LiteratureArticle Details

PMID: 6787589 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 1 ·1981-01-00 ·Pages 504-8

Lin LC, Putnam FW

Abstract

We have determined the complete amino acid sequence of a tryptic Fc delta fragment generated from an intact human IgD (WAH); it is 226 residues long and includes the second (C delta 2) and the third (C delta 3) constant domains of the delta chain. Comparison of the homology of the Fc sequence of the five human immunoglobulin classes suggests that either the delta-chain gene evolved from the alpha-chain gene soon after the divergence of a mu-alpha common ancestor or it evolved from an ancestral gene distinct from both the mu-alpha and the gamma-epsilon common ancestors. Comparative study using a spatial model of the Fc region indicates that the structure of the C delta 3 domain differs extensively from that of the carboxy-terminal domains of other heavy chain classes; this, together with the unique hinge region structure, probably reflects the biological role of IgD as a receptor molecule on the B-lymphocyte surface.

MeSH Terms

Amino Acid Sequence Biological Evolution Humans Immunoglobulin D Immunoglobulin Fc Fragments Immunoglobulin Heavy Chains Immunoglobulin alpha-Chains Immunoglobulin delta-Chains Immunoglobulin epsilon-Chains Immunoglobulin gamma-Chains Immunoglobulin mu-Chains Protein Conformation

Chemicals

Immunoglobulin D Immunoglobulin Fc Fragments Immunoglobulin Heavy Chains Immunoglobulin alpha-Chains Immunoglobulin delta-Chains Immunoglobulin epsilon-Chains Immunoglobulin gamma-Chains Immunoglobulin mu-Chains

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lin L C

Putnam F W

References (25)

25 references, click to expand

The covalent structure of an entire gammaG immunoglobulin molecule.
Proc Natl Acad Sci U S A. 1969 May;63(1):78-85 PMID: 5257969
Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression.
Nature. 1980 Jun 12;285(5765):450-6 PMID: 6772957
NH2-terminal amino acid sequence of the Fc fragment of IgD resembles IgE and IgG sequences.
Nature. 1975 Apr 24;254(5502):723-5 PMID: 1124134
Complete covalent structure of a human IgA1 immunoglobulin.
Science. 1976 Sep 10;193(4257):1017-20 PMID: 821146
Structure and function of the constant regions of immunoglobulins.
Q Rev Biophys. 1976 May;9(2):135-80 PMID: 785525
Crystallographic structure studies of an IgG molecule and an Fc fragment.
Nature. 1976 Dec 2;264(5585):415-20 PMID: 1004567
Sites of "spontaneous" degradation of IgD.
J Immunol. 1977 Jun;118(6):2138-44 PMID: 405424
Carboxypeptidase Y in sequence determination of peptides.
Methods Enzymol. 1977;47:84-93 PMID: 927202
Three-dimensional structure of an intact human immunoglobulin.
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5140-4 PMID: 270751
Lymphocyt membrane IgD.
Immunol Rev. 1977;37:210-8 PMID: 338466
Structural studies of human IgD paraproteins.
Immunol Rev. 1977;37:25-49 PMID: 338467
Lymphocyte surface IgD and IgM in Macaca monkeys: ontogeny, tissue distribution and occurrence on individual lymphocytes.
Immunology. 1977 Dec;33(6):865-72 PMID: 412779
Structure and function of serum and membrane immunoglobulin D (IgD).
Contemp Top Mol Immunol. 1978;7:1-49 PMID: 103684
The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells.
Immunol Rev. 1979;43:69-95 PMID: 83290
Identification of an IgD-like surface immunoglobulin on rabbit lymphocytes.
Eur J Immunol. 1979 Jan;9(1):13-6 PMID: 436925
Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene.
Cell. 1979 Oct;18(2):559-68 PMID: 115593
Presence of serum IgD and IgD-containing plasma cells in the mouse.
Eur J Immunol. 1979 Jun;9(6):490-2 PMID: 115697
Cross-reactivity of rat, mouse, and human IgD.
J Immunol. 1979 Dec;123(6):2751-5 PMID: 115921
Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.
Science. 1979 Dec 14;206(4424):1303-6 PMID: 117549
Structural studies of human IgD: isolation by a two-step purification procedure and characterization by chemical and enzymatic fragmentation.
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6572-6 PMID: 293745
Mouse Cmu heavy chain immunoglobulin gene segment contains three intervening sequences separating domains.
Nature. 1980 Apr 3;284(5755):452-5 PMID: 6767197
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain.
Cell. 1980 Jun;20(2):303-12 PMID: 6771019
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.
Cell. 1980 Jun;20(2):313-9 PMID: 6771020
Origins of immunoglobulin heavy chain domains.
J Mol Evol. 1980 May;15(2):113-27 PMID: 6772794
Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin.
Science. 1973 Oct 19;182(4109):287-91 PMID: 4742735

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.78.1.504

Published

1981-01-00

Pages

504-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC319082

Subset

Grants

NCI NIH HHS · CA08497 · United States

External Links

PubMed source DOI: 10.1073/pnas.78.1.504 PMC Full Text View journal details

Analysis Services

Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function.

Contact

WeChat Official Account