Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs.

Cell ·Vol. 10 ·No. 4 ·1977-04-00 ·Pages 559-70

Proudfoot NJ

Abstract

The 3' noncoding regions of rabbit and human beta-globin mRNAs, 95 and 134 nucleotides in length, have been sequenced. Furthermore, these and previous studies (Baralle, 1977; Proudfoot, 1976a, 1976b) have established about one half of the 589 nucleotide sequence of rabbit beta-globin mRNA, including all of the noncoding region. These sequence studies took advantage of the plus and minus gel-sequencing procedure originally described by Sanger and Coulson (1975) and recently adapted by G.G. Brownlee and E.M. Cartwright (manuscript in preparation). The human and rabbit 3' noncoding region sequences are extensively homologous, except that the human sequence has an addition of 39 nucleotides as compared with rabbit. This extra sequence may have arisen by gene duplication.

MeSH Terms

Animals Base Sequence DNA/biosynthesis Genetic Code Globins Humans Nucleic Acid Hybridization Nucleotides/analysis RNA, Messenger/analysis RNA-Directed DNA Polymerase/metabolism Rabbits Species Specificity

Chemicals

Nucleotides RNA, Messenger Globins DNA RNA-Directed DNA Polymerase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Proudfoot N J

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(77)90089-7

Published

1977-04-00

Pages

559-70

Language

English

Region

United States

NLM ID

0413066

Subset

Databases

GENBANK

J00093, J00094, J00096, J00158, J00159, J00160, J00161, J00162, J00163, J00164, J00165, J00166, J00167, J00168, J00169, J00170, J00171, J00172, J00173, J00174, J00175, J00177, J00178, J00179, J00659, K01239, K01890, K02544, M18047, M19067

External Links

PubMed source DOI: 10.1016/0092-8674(77)90089-7 View journal details

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Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs.

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