Home LiteratureArticle Details

PMID: 6795955 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Cyclic neutropenia. A tale of two brothers and their family.

The American journal of pediatric hematology/oncology ·Vol. 3 ·No. 2 ·1981-00-00 ·Pages 127-33

Lange RD, Crowder CG, Cruz P, Hawkinson SW, Lozzio CB, Machado E, Painter P, Terry W, Jones JB

Abstract

A family history encompassing four generations is presented. Definite cyclic neutropenia has been noted in two generations. In one member, the symptoms abated as she grew older. One 12-year-old member died of clostridial septicemia secondary to gangrene of the terminal ileum. At autopsy he was found to have amyloidosis. A trial of lithium carbonate therapy was carried out in a 7-year-old male but a positive hematologic response was not obtained.

MeSH Terms

Adolescent Adult Aged Agranulocytosis/genetics Amyloidosis/complications,pathology Child Female Humans Leukocyte Count Lithium/therapeutic use Lithium Carbonate Male Middle Aged Neutropenia/drug therapy,genetics,pathology Pedigree Periodicity Syndrome

Chemicals

Lithium Carbonate Lithium

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Lange R D

Crowder C G

Cruz P

Hawkinson S W

Lozzio C B

Machado E

Painter P

Terry W

Jones J B

Article Info

Journal

The American journal of pediatric hematology/oncology

Abbr.

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Published

1981-00-00

Pages

127-33

Language

English

Region

United States

NLM ID

7908071

Subset

Grants

NIADDK NIH HHS · AM 18314 · United States

NHLBI NIH HHS · HL 10567 · United States

NHLBI NIH HHS · HL 15647 · United States

External Links

PubMed source

Analysis Services

Cyclic neutropenia. A tale of two brothers and their family.

Contact

WeChat Official Account