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LiteratureArticle Details
PMID: 6806287
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.
Abstract
A methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. This RNA-pentose methylase modifies adenosine-1067 of Escherichia coli 23 S rRNA.
MeSH Terms
Adenosine
Anti-Bacterial Agents/pharmacology
Base Sequence
Drug Resistance, Microbial
Methyltransferases/metabolism
Nucleic Acid Conformation
RNA, Ribosomal
Ribonuclease T1
Ribosomes/enzymology
Streptomyces/enzymology
Substrate Specificity
Thiostrepton/pharmacology
Chemicals
Anti-Bacterial Agents
RNA, Ribosomal
Methyltransferases
rRNA (adenosine-O-2'-)methyltransferase
Ribonuclease T1
Thiostrepton
Adenosine
Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
0021-9258
Published
1982-07-25
Pages
7915-7
Language
English
Region
United States
NLM ID
2985121R
Subset
IM
Grants
NIGMS NIH HHS · GM 26756 · United States
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