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PMID: 6806903 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.

Science (New York, N.Y.) ·Vol. 217 ·No. 4555 ·1982-07-09 ·Pages 157-8

Faustman D, Lacy P, Davie J, Hauptfeld V

Abstract

Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.

MeSH Terms

Animals Complement System Proteins Diabetes Mellitus, Experimental/immunology Erythrocytes/immunology Graft Survival Histocompatibility Antigens Class II/immunology Immune Sera Immunization Immunosuppression Therapy Islets of Langerhans Transplantation Lymphocytes/immunology Male Mice Mice, Inbred C57BL Transplantation, Homologous

Chemicals

Histocompatibility Antigens Class II Immune Sera Complement System Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Faustman D

Lacy P

Davie J

Hauptfeld V

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6806903

Published

1982-07-09

Pages

157-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI-12734 · United States

NIADDK NIH HHS · AM-01226 · United States

NIGMS NIH HHS · GM-07200 · United States

External Links

PubMed source DOI: 10.1126/science.6806903 View journal details

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Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.

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