Modulation of the immune response by passive antibodies. IV. Effects of IgG1 and IgG2 anti-hapten antibodies.

Immunology ·Vol. 35 ·No. 1 ·1978-07-00 ·Pages 129-32

Neveu PJ, Micusan VV, Fafard A, Borduas AG

Abstract

The effects of IgG1 and IgG2 anti-hapten antibodies waere studied on celluar and humoral reactions induced by immunization with a hapten-carrier complex. IgG2 was shown to depress delayed hypersensitivity reactions to the carrier and to enhance anaphylactic reactions to both the hapten and the carrier whereas IgG1 appeared to have no activity except a little enhancing effect on antibody synthesis to the carrier. The regulatory role of IgG2 antibodies, which were cytophilic for macrophages, in the immune response to a hapten-carrier conjugate is discussed.

MeSH Terms

Anaphylaxis Animals Antibody Formation Female Guinea Pigs Haptens Hypersensitivity, Delayed Immunity Immunity, Cellular Immunity, Maternally-Acquired Immunoglobulin G

Chemicals

Haptens Immunoglobulin G

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Neveu P J

Micusan V V

Fafard A

Borduas A G

References (14)

14 references, click to expand

PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.
Methods Med Res. 1964;10:94-102 PMID: 14284950
Are cellular and humoral components of the immune response linked by a dispatcher cell?
Int Arch Allergy Appl Immunol. 1977;53(1):88-92 PMID: 838517
Suppression or augmentation of the antihapten response in mice by antibodies of different specificities.
J Exp Med. 1973 Jul 1;138(1):103-16 PMID: 4123826
Antigenic specificities of antibodies suppressing induction of delayed hypersensitivity in mice to dinitrophenylated proteins.
Immunology. 1973 Oct;25(4):541-55 PMID: 4127727
Properties of antibodies cytophilic for macrophages.
J Exp Med. 1966 Jan 1;123(1):119-44 PMID: 4159249
Regulation of the immune response. VII. In vitro immunosuppression by F(ab') 2 or intact IgG antibodies.
Immunology. 1973 Apr;24(4):735-50 PMID: 4574800
Modulation of the immune response by passive antibodies. I. Anti-hapten antibodies enhanced delayed hypersensitivity to the carrier and depressed antibody synthesis to the hapten.
Int Arch Allergy Appl Immunol. 1975;48(5):698-705 PMID: 48508
Immunodeviation by passive antibody, an expression of selective immunodepression. I. Action of guinea pig IgG 1 and IgG 2 anti-hapten antibodies.
Eur J Immunol. 1973 Feb;3(2):90-5 PMID: 4541422
The mechanism of a hapten-specific helper effect in mice.
J Immunol. 1973 Oct;111(4):1250-6 PMID: 4728684
Macrophage-bound antigens. I. Induction of delayed hypersensitivity and priming for production of serum antibodies in guinea pigs.
J Immunol. 1972 Aug;109(2):244-54 PMID: 5047370
Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment.
J Exp Med. 1969 Jun 1;129(6):1183-201 PMID: 5305714
Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses.
J Immunol. 1976 Jul;117(1):40-7 PMID: 1084370
Role of macrophages in in vitro induction of T-helper cells.
Nature. 1975 Mar 27;254(5498):352-4 PMID: 1090850
Cytophilic antibodies in passive aibody induced immune suppression or enhancement.
Nature. 1970 May 9;226(5245):550-1 PMID: 5442353

Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1978-07-00

Pages

129-32

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1457217

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

Modulation of the immune response by passive antibodies. IV. Effects of IgG1 and IgG2 anti-hapten antibodies.

Contact

WeChat Official Account