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PMID: 680949 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The influence of chemotactic factors on neutrophil adhesiveness.

Inflammation ·Vol. 3 ·No. 1 ·1978-03-00 ·Pages 37-48

O'Flaherty JT, Kreutzer DL, Ward PA

Abstract

The ability of several chemotactic factors to alter polymorphonuclear neutrophil (PMN) adhesiveness to nylon fibers was studied. Partly purified bacterial chemotactic factor, the isolated chemotactic fragment of human C5, and the chemotactic synthetic tripeptide, formyl-methionyl-leucyl-phenylalanine, transiently enhanced the nylon fiber adhesiveness of rabbit peritoneal PMSs. The capacity of these chemotactic factors to augment PMN adherence closely paralleled their ability to aggregate PMNs in suspension and to induce neutropenia when infused into rabbits. However, at least a portion of the adhreence-augmenting capacity of these agents was independent of their ability to induce PMN aggregation. Thus, chemotactic factors appear to transiently enhance PMN adhesiveness to a variety of surfaces. This hyper-adhesiveness may underlie the augmented nylon fiber adherence, aggregation, and neutropenia induced by these factors.

MeSH Terms
Animals Calcium/pharmacology Cell Adhesion Cell Aggregation Chemotaxis, Leukocyte Complement C5 Granulocytes/physiology Humans In Vitro Techniques Magnesium/pharmacology Neutrophils/physiology Nylons Rabbits
Chemicals
Complement C5 Nylons Magnesium Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
O'Flaherty J T
Kreutzer D L
Ward P A
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28 references, click to expand
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Article Info
Journal
Inflammation
Abbr.
Inflammation
ISSN
0360-3997
DOI
10.1007/BF00917320
Published
1978-03-00
Pages
37-48
Language
English
Region
United States
NLM ID
7600105
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00917320 View journal details
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